2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide

2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide is a small molecule that functions as an inhibitor of human Matrix Metalloproteinase 12 (MMP12). MMP12, also known as macrophage elastase, is an enzyme involved in the breakdown of extracellular matrix components, particularly elastin, and plays a role in tissue remodeling and inflammatory responses. By inhibiting MMP12 activity, this compound helps maintain the structural integrity of the extracellular matrix and reduces inflammation. It has been investigated in preclinical models for its potential therapeutic benefits in conditions such as chronic obstructive pulmonary disease (COPD), atherosclerosis, certain types of cancer, neurodegenerative diseases, and abdominal aortic aneurysms.

Other names

2-((4-fluorophenyl)sulfonylamino)-N-oxo-ethanamide2-(4-fluorobenzenesulfonamido)-N-oxoacetamideN~2~-[(4-fluorophenyl)sulfonyl]-N-oxoglycinamide4-fluoro-N-(2-nitroso-2-oxoethyl)benzenesulfonamide2-[(4-fluorophenyl)sulfonylamino]-N-oxoacetamide